It was a tightly contested first leg tie as Nigeria had to settle for a 0-0 draw in Ghana on Friday.
It was indeed a frustrating night for the visitors as VAR overruled a decision to award them a penalty in the first leg of a World Cup play-off between the continental giants.
A review of the decision in the closing stages of the West African showdown in Kumasi found that Ghana midfielder Iddrisu Baba was fouled before he handled it.
Ghana came closest to breaking the deadlock with Nigerian goalkeeper Francis Uzoho pulling off a superb save to deny Fatahu Ishaku in the first half.